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谢英

副教授 硕士生导师

谢英 博士, 副教授, 硕士生导师

Associate Prof. Ying Xie

Tel: (+8610) 82805351 (Office)

Email: bmuxieying@bjmu.edu.cn

    谢英,1972年8月生于内蒙古。1996年毕业于北京师范大学化学系物理化学专业,获理学硕士学位。2005年获得北京大学药剂学博士学位。现任北京大学365滚球直播副教授,主要从事药学院长学制《物理化学》的教学,作为副主编及参编药学专业必修课教材及专著13部。

    1993至1996年从事生物抗氧化过程酶催化机理的研究,参加两项国家自然科学基金资助项目;1996年以来从事药剂学研究,为多项新药制剂提供技术服务,负责北大方正创新药物研究基金1项,主持或作为共同申请人负责国家自然科学基金资助项目3项,作为主要研究人员参加国家重大科学研究计划(973)《纳米技术改善难溶性药物功效的应用基础》和重大新药创制:新制剂与新释药系统技术平台的研究工作。发表论文30余篇,申请/授权专利10/4项。近年来获得的奖励主要包括北京大学医学部教学优秀奖(2005, 2009, 2012, 2016),北京大学药学院优秀党员(2010),北京大学工会先进个人(2007, 2015),北京大学医学部优秀工会工作者(2010, 2014, 2017),教育部科技进步二等奖(2004),DOVE PRESS首届中文摘要视频大赛奖(2015年)等。担任《Journal of Chinese Pharmaceutical Sciences》、《International Journal of Pharmaceutics》、《J Microencapsulation》、《Colloid and Surface, B》、《北京大学学报医学版》等学术期刊的审稿人。

 

主要科研方向

新型药物递送系统及靶向给药

 

主要研究内容

脑靶向给药系统的研究

多尺度计算模拟与实验相结合探讨新型递药系统中的分子作用机制

 

代表论文

1.  Xie Ying, Ye Liya, Zhang Xiaobin,Cui Wei, Lou Jinning, Tauneji Nagai, Hou Xinpu*. Transport of nerve growth factor encapsulated into liposomes across the blood–brain barrier: In vitro and in vivo studies. J. Control. Release , 2005, 105(1-2):106-119.

2. Xie Ying, Wang Fei, Li Feifei, Li Dongsheng, Deng Lili, Effects of Binuclear Copper (II) Threonine Complex on Blood Glucose, Lipids and Protection of the Hearts and Kidneys in Diabetic Mice. J. Chin. Pharm. Sci ,2007, 16(1): 14-17.

3. Zheng T.-T.,Zhou H.-X.,Chen R.-Q.,Li Z-Y.,Xie Y. *,Jia H.-M.*. Improved Brain Uptake of 99mTcN-NOET loaded by Targeted Sterically Stabilized Liposomes in ICR Mice. J Label Compd Radiopharm , 2009, 52(S1):S80。

4. Zhou He-Xiang, Chen Rui-Qin, Sun Hui, Zhang Pei-Ran, Jia Hong-Mei*, Ying Xie*,Bio-distributions of [125I]Spiro-I brain targeted liposomes in mice, J. Chin. Pharm. Sci , 2010, 19(1): 47-51。

5. Zhang Pei-ran, Tu Ying-feng, Wang Shuo, Wang Yi-hui,Xie Ying *, Li Miao *, Jin Yiguang, Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery, J. Chin. Pharm. Sci, 2011, 20(4):390-396.

6. Sun Hui, Zhang Xian-Hua, Wang Shuo, Tu Ying-Feng, Zhao Rong-Sheng*, Xie Ying*. Preparation and characterization of oleanolic acid loaded solid lipid nanoparticles for oral administration, J. Chin. Pharm. Sci, 2011, 20(3):259-265.

7. Yu Yu-Ping , Wang Qi , Liu Ying-Chun*, Xie Ying*,Molecular basis for the targeted binding of RGD-containing peptide to integrin aVb3, Biomaterials , 2014, 35(5):1667-1675.[IF 8.312]

8. Luo Qi#, Wang Yihui#, Yang hongge, Liu Chang, Ding Yuan, Xu Haifeng, Wang Qi, Liu Yingchun*, Xie Ying*. Modeling the Interaction of Interferon α-1b to Bovine Serum Albumin as a Drug Delivery System. J Phys Chem B.  2014, 118(29):8566-8574. [IF 3.377]

9. Liu Chang#, Luo Qi#, Tu Ying-Feng, Wang Gui-Ling, Liu Ying-Chun*, Xie Ying*. Drug-carrier interaction analysis in the cell penetrating peptide-modified liposomes for doxorubicin loading. J Microencapsul .2015, 32(8):745-54. [IF 1.86]

10. Ding Yuan #, Sun Dan#, Wang Gui-Ling, Yang Hong-Ge, Xu Hai-Feng, Chen Jian-Hua*, Xie Ying*, Wang Zhi-Qiang. An efficient PEGylated liposomal nanocarrier containing cell penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery. Int J Nanomedicine . 2015, 10: 6199-6124. [IF 4.383]

11. Lin Shao-Hui, Cui Wei, Wang Gui-Ling, Meng Shuai, Liu Ying-Chun, Jin Hong-Wei, Zhang Liang-Ren, Xie Ying*, Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles. Drug Des Devel Ther. 2016, 10: 2973-2987. [IF 2.822]

12. Liu Chang#, Liu Xiao-Na#, Wang Gui-Ling, Hei Yu, Meng Shuai, Yang Ling-Fei, Yuan Lan*, Xie Ying*, A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells, Int J Nanomedicine . 2017, 12: 2407-2425. [IF 4.300]

13. Ding Yuan#, Cui Wei#, Sun Dan, Wang Gui-Ling, Hei Yu, Meng Shuai, Chen Jian-Hua, Xie Ying*, Wang Zhi-Qiang. In vivo study of doxorubicin-loaded cell penetrating peptide modified pH sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/C-nude mice bearing human breast tumors. Drug Des Devel Ther . 2017, 11:3105-3117. [IF 2.822]